2021年度 業績

Araya J, Saito N, Hosaka Y, Ichikawa A, Kadota T, Fujita Y, Minagawa S, Hara H, Fujimoto S, Kawamoto H, Watanabe N, Ito A, Okuda K, Miyagawa H, Watanabe J, Takekoshi D, Utsumi H, Yoshida M, Hashimoto M, Wakui H, Ito S, Numata T, Mori S, Matsudaira H, Hirano J, Ohtsuka T, Nakayama K, Kuwano K. Impaired TRIM16-mediated lysophagy in chronic obstructive pulmonary disease pathogenesis. J Immunol 2021; 207(1): 65-76.

 Hara H, Miyagawa H, Araya J, Minagawa S, Numata T, Umezawa Y, Asahina A, Nakagawa H, Kuwano K. Effect of anti-interleukin-17 biologics on Krebs von den Lungen-6 level in patients with psoriasis. J Dermatol 2021; 48(6): 886-93.

 Hara H, Okuda K, Araya J, Utsumi H, Takekoshi D, Ito S, Wakui H, Minagawa S, Numata T, Kuwano K. Possible relationship between esophageal dilatation and severity of M. abscessus pulmonary disease. PLoS One 2021; 16(12): e0261866.

 Numata T, Araya J, Miyagawa H, Okuda K, Fujita Y, Utsumi H, Takekoshi D, Hashimoto M, Minagawa S, Ishikawa T, Hara H, Kuwano K. Effectiveness of switching biologics for severe asthma patients in Japan: a single-center retrospective study. J Asthma Allergy 2021; 14: 609-18.

 Takasaka N, Hosaka Y, Fukuda T, Shinfuku K, Chida K, Shibata S, Kojima A, Hasegawa T, Yamada M, Yamanaka Y, Seki A, Seki Y, Ishikawa T, Kuwano K. Impact of emphysema on the prognosis of Mycobacterium avium complex pulmonary disease. Respir Med 2022; 192: 106738.

 Kazuyori T, Sato A, Morimoto Y, Kuwano K. Analysis of SARS-CoV-2 PCR and chest CT findings at a single facility in Tokyo (Machida Municipal Hospital). 2021; 2021: 6680232.

 Tone K, Stappers MHT, Hatinguais R, Dambuza IM, Salazar F, Wallace C, Yuecel R, Morvay PL, Kuwano K, Willment JA, Brown GD. MelLec exacerbates the pathogenesis of Aspergillus fumigatus-induced allergic inflammation in mice. Front Immunol 2021; 12: 675702.

 Fujita Y, Hoshina T, Matsuzaki J, Yoshioka Y, Kadota T, Hosaka Y, Fujimoto S, Kawamoto H, Watanabe N, Sawaki K, Sakamoto Y, Miyajima M, Lee K, Nakaharai K, Horino T, Nakagawa R, Araya J, Miyato M, Yoshida M, Kuwano K, Ochiya T. Early prediction of COVID-19 severity using extracellular vesicle COPB2. J Extracell Vesicles 2021; 10(8): e12092.

 Yoshida M, Worlock KB, Huang N, Lindeboom RGH, Butler CR, Kumasaka N, Dominguez Conde C, Mamanova L, Bolt L, Richardson L, Polanski K, Madissoon E, Barnes JL, Allen-Hyttinen J, Kilich E, Jones BC, de Wilton A, Wilbrey-Clark A, Sungnak W, Pett JP, Weller J, Prigmore E, Yung H, Mehta P, Saleh A, Saigal A, Chu V, Cohen JM, Cane C, Iordanidou A, Shibuya S, Reuschl AK, Herczeg IT, Argento AC, Wunderink RG, Smith SB, Poor TA, Gao CA, Dematte JE; NU SCRIPT Study Investigators, Reynolds G, Haniffa M, Bowyer GS, Coates M, Clatworthy MR, Calero-Nieto FJ, Göttgens B, O'Callaghan C, Sebire NJ, Jolly C, De Coppi P, Smith CM, Misharin AV, Janes SM, Teichmann SA, Nikolić MZ, Meyer KB. Local and systemic responses to SARS-CoV-2 infection in children and adults. Nature 2022; 602(7896): 321–7.

 Kadota T, Fujita Y, Araya J, Watanabe N, Fujimoto S, Kawamoto H, Minagawa S, Hara H, Ohtsuka T, Yamamoto Y, Kuwano K, Ochiya T. Human bronchial epithelial cell-derived extracellular vesicle therapy for pulmonary fibrosis via inhibition of TGF-β-WNT crosstalk. J Extracell Vesicles 2021; 10(10): e12124.

 Miyagawa H, Hara H, Araya J, Minagawa S, Numata T, Umezawa Y, Asahina A, Nakagawa H, Kuwano K. Characteristics of anti-IL-17/23 biologics-induced interstitial pneumonia in patients with psoriasis. PLoS One 2021; 16(1): e0245284.[l1] [C2] 

 Hosoda C, Ishiguro T, Uozumi R, Ueda M, Takata N, Takayanagi N. Characteristics of pulmonary cryptococcosis in patients with rheumatoid arthritis. BMJ Open Respir Res 2021; 8(1): e000805.

 Hosaka Y, Araya J, Fujita Y, Kuwano K. Role of chaperone-mediated autophagy in the pathophysiology including pulmonary disorders. Inflamm Regen 2021; 41(1): 29.

 Yamakawa H, Takemura T, Sato S, Nakamura T, Nishizawa T, Oba T, Kawabe R, Akasaka K, Amano M, Kuwano K, Matsushima H. The Usefulness of a Transbronchial Lung Cryobiopsy for Diffuse Bronchiolitis. Intern Med 2021; 60(9): 1457-62[l3] [C4] .

 Yamakawa H, Ogura T, Kameda H, Kishaba T, Iwasawa T, Takemura T, Kuwano K. Decision-making strategy for the treatment of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). J Clin Med 2021; 10(17): 3806.[l5] [C6] 

 Yamakawa H, Sato S, Nakamura T, Nishizawa T, Kawabe R, Oba T, Horikoshi M, Akasaka K, Amano M, Kuwano K, Sasaki H, Matsushima H. Prognostic value of radiological findings indeterminate for UIP pattern and anterior upper lobe honeycomb-like lesion in chronic fibrosing interstitial lung disease associated with MPO-ANCA. BMC Pulm Med 2021; 21(1): 346.

 Yamakawa H, Tsukahara Y, Sato S, Ohta H, Kida G, Nakamura T, Nishizawa T, Kawabe R, Oba T, Akasaka K, Amano M, Kuwano K, Sasaki H, Takemura T, Matsushima H. Impact of progressive fibrosing interstitial lung disease (ILD) in ILD patients complicated with secondary spontaneous pneumothorax. Sarcoidosis Vasc Diffuse Lung Dis 2022; 38(4): e2021042.

 Saito Y, Sasaki S, Oikado K, Tominaga J, Sata M, Sakai F, Kato T, Iwasawa T, Kenmotsu H, Kusumoto M, Baba T, Endo M, Fujiwara Y, Sugiura H, Yanagawa N, Ito Y, Sakamoto T, Ohe Y, Kuwano K. Radiographic features and poor prognostic factors of interstitial lung disease with nivolumab for non-small cell lung cancer. Cancer Sci 2021; 112(4): 1495-1505.[l7] [C8] 

 Sata M, Sasaki S, Oikado K, Saito Y, Tominaga J, Sakai F, Kato T, Iwasawa T, Kenmotsu H, Kusumoto M, Baba T, Endo M, Fujiwara Y, Sugiura H, Yanagawa N, Ito Y, Sakamoto T, Ohe Y, Kuwano K. Treatment and relapse of interstitial lung disease in nivolumab-treated patients with non-small cell lung cancer. Cancer Sci 2021; 112(4): 1506-13.[l9] [C10] 

 Kawano Y, Obana M, Nagata M, Mano Y, Katsuyama M, Yamamoto Y, Maeda-Minami A, Negishi K, Takagi M, Shimada S, Aoyama T. The antiplatelet effect of mirtazapine is mediated by co-blocking 5-HT2A and α2-adrenergic receptors on platelets: An in vitro human plasma-based study. Eur J Pharmacol 2022; 917: 174640.

 Hisata S, Bando M, Homma S, Kataoka K, Ogura T, Izumi S, Sakamoto S, Watanabe K, Saito Y, Shimizu Y, Kato M, Nishioka Y, Hara H, Waseda Y, Tanino Y, Yatera K, Hashimoto S, Mukae H, Inase N, Diffuse Lung Diseases Research Group of the Ministry of Health, Labour and Welfare, Japan. Safety and tolerability of combination therapy with pirfenidone and nintedanib for idiopathic pulmonary fibrosis: a multicenter retrospective observational study in Japan. Respir Investig 2021; 59(6): 819-26.

 Seed RI, Kobayashi K, Ito S, Takasaka N, Cormier A, Jespersen JM, Publicover J, Trilok S, Combes AJ, Chew NW, Chapman J, Krummel MF, Lou J, Marks J, Cheng Y, Baron JL, Nishimura SL. A tumor-specific mechanism of T reg enrichment mediated by the integrin αvβ8. Sci Immunol 2021; 6(57): eabf0558.

 Okuma Y, Shimokawa M, Hashimoto K, Mizutani H, Wakui H, Murakami S, Atagi S, Minato K, Seike M, Ohe Y, Kubota K, Tokyo Cooperative Oncology Group. Uncommon EGFR mutations conducted with osimertinib in patients with NSCLC: a study protocol of phase 2 study (UNICORN/TCOG1901). Future Oncol 2022; 18(5): 523-31.

 Kumagai S, Koyama S, Itahashi K, Tanegashima T, Lin Y, Togashi Y, Kamada T, Irie T, Okumura G, Kono H, Ito D, Fujii R, Watanabe S, Sai A, Fukuoka S, Sugiyama E, Watanabe G, Owari T, Nishinakamura H, Sugiyama D, Maeda Y, Kawazoe A, Yukami H, Chida K, Ohara Y, Yoshida T, Shinno Y, Takeyasu Y, Shirasawa M, Nakama K, Aokage K, Suzuki J, Ishii G, Kuwata T, Sakamoto N, Kawazu M, Ueno T, Mori T, Yamazaki N, Tsuboi M, Yatabe Y, Kinoshita T, Doi T, Shitara K, Mano H, Nishikawa H. Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments. Cancer Cell 2022; 40(2): 201-18.

 Stephenson E, Reynolds G, Botting RA, Calero-Nieto FJ, Morgan MD, Tuong ZK, Bach K, Sungnak W, Worlock KB, Yoshida M, Kumasaka N, Kania K, Engelbert J, Olabi B, Spegarova JS, Wilson NK, Mende N, Jardine L, Gardner LCS, Goh I, Horsfall D, McGrath J, Webb S, Mather MW, Lindeboom RGH, Dann E, Huang N, Polanski K, Prigmore E, Gothe F, Scott J, Payne RP, Baker KF, Hanrath AT, Schim van der Loeff ICD, Barr AS, Sanchez-Gonzalez A, Bergamaschi L, Mescia F, Barnes JL, Kilich E, de Wilton A, Saigal A, Saleh A, Janes SM, Smith CM, Gopee N, Wilson C, Coupland P, Coxhead JM, Kiselev VY, van Dongen S, Bacardit J, King HW; Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID-19 BioResource Collaboration, Rostron AJ, Simpson AJ, Hambleton S, Laurenti E, Lyons PA, Meyer KB, Nikolić MZ, Duncan CJA, Smith KGC, Teichmann SA, Clatworthy MR, Marioni JC, Göttgens B, Haniffa M. Single-cell multi-omics analysis of the immune response in COVID-19. Nat Med 2021; 27(5): 904–16.

 Katano T, Sekine A, Ikeda S, Yamakawa H, Misumi T, Okabayashi H, Okuda R, Kitamura H, Baba T, Komatsu S, Hagiwara E, Ogura T. Predictive factors for the long-term use of pirfenidone in patients with fibrosing interstitial lung disease. Respir Investig 2021; 59(4): 414-20.

 Nakamura Y, Fukutomi Y, Sekiya K, Kajiwara K, Kawasaki Y, Fujita N, Nagayama K, Iwata M, Iwamoto K, Yano K, Hamada Y, Watai K, Ryu K, Hayashi H, Kamide Y, Taniguchi M. Low-dose mepolizumab is effective as an add-on therapy for treating long-lasting peripheral neuropathy in patients with eosinophilic granulomatosis with polyangiitis. Mid Rheumatol 2022; 32(2): 387-95.

 Nagayama K, Watai k, Sekiya K, Iwata M, Hashimoto Y, Nakamura Y, Miyake A, Ryu K, Hayashi H, Ohmatsu H, Kamide Y, Fukutomi Y, Taniguchi M. Association between the severity of chronic spontaneous urticaria and sleep-disordered breathing. Allergol Int 2022; 71(1): 103-8.

 Shimomura I, Watanabe N, Yamamoto T, Kumazaki M, Tada Y, Tatsumi K, Ochiya T, Yamamoto Y. Selective targeting of KRAS-driven lung tumorigenesis via unresolved ER stress. JCI Insight 2021; 6(7): 137876.

 Kanno T, Nakajima T, Yokoyama S, Asou H, Sasamoto S, Kamii Y, Hayashizaki K, Ouchi Y, Onodera T, Takahashi Y, Ikeda K, Hasegawa Y, Kinjo Y, Ohara O, Nakayama T, Endo Y. SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells. Commun Biol 2021; 4(1): 820.

 Otoshi R, Hagiwara E, Kitayama T, Yamaya T, Higa K, Murohashi K, Sato Y, Tabata E, Shintani R, Okabayashi H, Ikeda S, Niwa T, Nakazawa A, Oda T, Okuda R, Sekine A, Kitamura H, Baba T, Komatsu S, Ogura T. Clinical characteristics of Japanese patients with moderate to severe COVID-19. J Infect Chemother 2021; 27(6): 895-901.

 Yamaya T, Hagiwara E, Baba T, Kitayama T, Murohashi K, Higa K, Sato Y, Otoshi R, Tabata E, Shintani R, Okabayashi H, Ikeda S, Niwa T, Nakazawa A, Oda T, Okuda R, Sekine A, Kitamura H, Komatsu S, Ogura T. Serum Krebs von den Lungen-6 levels are associated with mortality and severity in patients with coronavirus disease 2019. Respir Investig 2021; 59(5): 596-601.

 Takeda K, Suzuki J, Watanabe A, Arai T, Koiwa T, Shinfuku K, Narumoto O, Kawashima M, Fukami T, Tamura A, Nagai H, Matsui H, Kamei K. High detection rate of azole-resistant Aspergillus fumigatus after treatment with azole aitifungal drugs among patients with chronic pulmonary aspergillosis in a single hospital setting with low azole resistance. Med Mycol 2021; 59(4): 327-34.

Araya J, Kuwano K. Cellular senescence-an aging hallmark in chronic obstructive pulmonary disease pathogenesis. Respir Investig 2022; 60(1): 33-44.

 Yamakawa H, Ogura T, Kameda H, Kishaba T, Iwasawa T, Takemura T, Kuwano K. Decision-making strategy for the treatment of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). J Clin Med 2021; 10(17): 3806.[l1] [C2] 

 Kadota T, Fujita Y, Araya J, Ochiya T, Kuwano K. Extracellular vesicle-mediated cellular crosstalk in lung repair, remodelling and regeneration. Eur Respir Rev 2022; 31(163): 210106.

 門田　宰, 桑野和善. 特発性肺線維症におけるエクソソーム研究. 呼吸器内科 2022; 41(2): 185-90.

 Kondoh Y, Makino S, Ogura T, Suda T, Tomioka H, Amano H, Anraku M, Enomoto N, Fujii T, Fujisawa T, Gono T, Harigai M, Ichiyasu H, Inoue Y, Johkoh T, Kameda H, Kataoka K, Katsumata Y, Kawaguchi Y, Kawakami A, Kitamura H, Kitamura N, Koga T, Kurasawa K, Nakamura Y, Nakashima R, Nishioka Y, Nishiyama O, Okamoto M, Sakai F, Sakamoto S, Sato S, Shimizu T, Takayanagi N, Takei R, Takemura T, Takeuchi T, Toyoda Y, Yamada H, Yamakawa H, Yamano Y, Yamasaki Y, Kuwana M; joint committee of Japanese Respiratory Society and Japan College of Rheumatology. 2020 guide for the diagnosis and treatment of interstitial lung disease associated with connective tissue disease. Respir Investig 2021; 59(6): 709-40.

Tone K, Hirano Y, Kuwano K. Iliopsoas gravity abscess secondary to a tuberculous empyema. Int J Mycobacteriol 2021; 10(3): 335-7. 

Tone K, Tamura T, Hagiwara S, Kuwano K, Makimura K. Pulmonary coinfection due to Mycobacterium abscessus subsp. massiliense and Cryptococcus neoformans var. grubii. Jpn J Infect Dis 2021; 74(6): 600-3.

Yamakawa H, Takemura T, Sato S, Nakamura T, Nishizawa T, Oba T, Kawabe R, Akasaka K, Amano M, Kuwano K, Matsushima H. The Usefulness of a Transbronchial Lung Cryobiopsy for Diffuse Bronchiolitis. Intern Med 2021; 60(9): 1457-62.[l1] [C2] 

奥田慶太郎, 原　弘道, 川本浩徳, 竹越大輔, 内海裕文, 和久井大, 皆川俊介, 沼田尊功, 荒屋　潤, 桑野和善. M. massiliense感染を合併した外因性リポイド肺炎の1例. 気管支学 2021; 43(6): 595-601.

Suzuki Y, Takasaka N, Matsubayashi S, Kojima A, Shinfuku K, Hasegawa T, Yamada M, Fujisaki I, Seki A, Seki Y, Ishikawa T, Kuwano K. Allergic bronchopulmonary aspergillosis in a patient with ankylosing spondylitis treated with adalimumab. Respirol Case Rep 2021; 9(8): e00805.

Chida K, Yamanaka Y, Sato A, Ito S, Takasaka N, Ishikawa T, Kuwano K. Solitary pulmonary nodule caused by pulmonary Mycobacterium lentiflavum infection. Respir Med Case Rep 2021; 34: 101510.

北村佳奈, 宇田川友克, 志村英二, 櫻井結華, 高橋恵里沙, 伊藤三郎, 沼田尊功, 小島博己. 比較的少量のシスプラチン累積投与後に発症した耳鳴症状に対して各種聴覚検査による経過観察を行った1例. 耳鼻展望 2021; 64(6): 331-8.

Miyamoto T, Tone K, Inaki S, Saito R, Maeda M, Nagano Y, Akutsu T, Furube A, Gochi M, Motohashi K, Koido S, Takagi M, Kuwano K. Pancreatic tuberculosis in an immunocompetent young female mimicking a malignant tumor: a case report and diagnostic radiological investigation. Clin Imaging 2022; 81: 114-7.

Sato S, Yamakawa H, Takemura T, Nakamura T, Oba T, Nishizawa T, Kawabe R, Akasaka K, Amano M, Matsushima H. Anti-PL-7 antibody-positive dermatomyositis with progressive interstitial pneumonia complicated with tracheal ulcer. Respir Med Case Rep 2021; 33: 101449.

Matsumoto S, Suzuki M, Matsubayashi S, Tsukada A, Kusaba Y, Katsuno T, Iikura M, Izumi S, Takeda Y, Hojo M, Sugiyama H. Refractory hemoptysis caused by severe pulmonary vein stenosis after multiple catheter ablations. Intern Med 2021; 60(20): 3279-84.